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2021

First-line avelumab in a cohort of 116 patients with metastatic Merkel cell carcinoma (JAVELIN Merkel 200): primary and biomarker analyses of a phase II study

D'Angelo SP, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ, Prinzi N, Hanna GJ, Hassel JC, Kiecker F, Georges S, Ellers-Lenz B, Shah P, Güzel G, Nghiem P

J Immunother Cancer. 2021 Jul;9(7):e002646. doi: 10.1136/jitc-2021-002646.

PMID: 34301810

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Extended T cell epitope landscape in Merkel cell polyomavirus large T and small T oncoproteins identified uniquely in cancer patients

Hansen UK, Lyngaa R, Ibrani D, Church CD, Verhaegen M, Dlugosz AA, Becker JC, Straten PT, Nghiem P, Hadrup SR

J Invest Dermatol. 2021 Jul 20;S0022-202X(21)01459-7. doi: 10.1016/j.jid.2021.06.027.

PMID: 34298058

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Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer?

Goff PH, Bhakuni R, Pulliam T, Lee JH, Hall ET, Nghiem P

Cancers (Basel). 2021 Jul 8;13(14):3415. doi: 10.3390/cancers13143415.

PMID: 34298632

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Spatial transcriptomics at subspot resolution with BayesSpace

Zhao E, Stone MR, Ren X, Guenthoer J, Smythe KS, Pulliam T, Williams SR, Uytingco CR, Taylor S, Nghiem P, Bielas JH, Gottardo R

Nat Biotechnol. 2021 Jun 3. doi: 10.1038/s41587-021-00935-2.

PMID: 34083791

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Three-year survival, correlates and salvage therapies in patients receiving first-line pembrolizumab for advanced Merkel cell carcinoma

Nghiem P, Bhatia S, Lipson EJ, Sharfman WH, Kudchadkar RR, Brohl AS, Friedlander PA, Daud A, Kluger HM, Reddy SA, Boulmay BC, Riker A, Burgess MA, Hanks BA, Olencki T, Kendra K, Church C, Akaike T, Ramchurren N, Shinohara MM, Salim B, Taube JM, Jensen E, Kalabis M, Fling SP, Moreno BH, Sharon E, Cheever MA, Topalian SL

J Immunother Cancer. 2021; 9(4): e002478.

PMID: 33879601

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Quality Is King: Fundamental Insights into Tumor Antigenicity from Virus-Associated Merkel Cell Carcinoma

Lahman MC, Paulson KG, Nghiem PT, Chapuis AG

J Invest Dermatol. 2021 Apr 13;S0022-202X(21)00999-4. doi: 10.1016/j.jid.2020.12.037

PMID: 33863500

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How we treat Merkel cell carcinoma: within and beyond current guidelines

Park SY, Doolittle-Amieva C, Moshiri Y, Akaike T, Parvathaneni U, Bhatia S, Zaba L, Nghiem P

Future Oncol. doi: 10.2217/fon-2020-1036

PMID: 33511866

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Immune checkpoint inhibitor therapy in HIV-associated Merkel cell carcinoma: A case series of 3 patients

Song Y Park, Candice Church, Nora A Alexander, Michi M Shinohara, Kelly G Paulson, Karl D Lewis, Nancy S Lee, Paul Nghiem

JAAD Case Rep. 2021 Feb; 8: 28–33.

PMID: 33490342

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Narrow excision margins are appropriate for Merkel cell carcinoma when combined with adjuvant radiation: Analysis of 188 cases of localized disease and proposed management algorithm

Erica S Tarabadkar, Teresa Fu, Kristina Lachance, Daniel S Hippe, Thomas Pulliam, Hannah Thomas, Janet Y Li, Christopher W Lewis, Coley Doolittle-Amieva, David R Byrd, Jeremy T Kampp, Upendra Parvathaneni, Paul Nghiem

J Am Acad Dermatol. 2021 Feb;84(2):340-347. doi: 10.1016/j.jaad.2020.07.079.

PMID: 32711093

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Lack of efficacy of radiation therapy plus PD-L1 blockade for Merkel cell carcinoma arising in a patient with chronic active Epstein-Barr virus infection

Okazaki A, Nakai K, Kusutani N, Kamo R, Fukunaga Y, Nagase K, Nghiem P, Tsuruta D.

Dermatol Ther. 2020 Dec 29;e14722.doi: 10.1111/dth.14722

PMID: 33373098

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2020

Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab

Murtuza Bharmal, Sandra Nolte, Céleste Lebbé, Laurent Mortier, Andrew S Brohl, Nicola Fazio, Jean-Jacquez Grob, Sara Pusceddu, Glenn J Hanna, Jessica C Hassel, Felix Kiecker, Barbara Ellers-Lenz, Marcis Bajars, Gülseren Güzel, Paul Nghiem, Matthias Hunger, Michael Schlichting, Mickaël Henry-Szatkowski, Sandra P D'Angelo

Future Oncol. 2020 Sep;16(27):2089-2099. doi: 10.2217/fon-2020-0426. Epub 2020 Sep 17.

PMID: 32938212

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Postoperative, Single-Fraction Radiation Therapy in Merkel Cell Carcinoma of the Head and Neck

Cook MM, Schaub SK, Goff PH, Fu A, Park SY, Hippe DS, Liao JJ, Apisarnthanarax S, Bhatia S, Tseng YD, Nghiem PT, Parvathaneni U

Adv Radiat Oncol. 2020 Jul 21 doi: 10.1016/j.adro.2020.07.003

PMID: 32838069

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Clinical Benefit of Baseline Imaging in Merkel Cell Carcinoma: Analysis of 584 Patients

Neha Singh, BS, Nora A. Alexander, BS, Kristina Lachance, MS, Christopher W. Lewis, MD, Aubriana McEvoy, MD, Gensuke Akaike, MD, David Byrd, MD, Sanaz Behnia, MD, Shailender Bhatia, MD, Kelly G. Paulson, MD, PhD, Paul Nghiem, MD, PhD

J Am Acad Dermatol . 2020 Jul 21;S0190-9622(20)32265-9. doi: 10.1016/j.jaad.2020.07.065.

PMID: 32707254

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The 6-4 Photoproduct Is the Trigger of UV-induced Replication Blockage and ATR Activation

Kai-Feng Hunga, Julia M. Sidorova, Paul Nghiem, and Masaoki Kawasumi

Proc Natl Acad Sci. 2020 May 22;201917196. doi: 10.1073/pnas.1917196117.

PMID: 32444488

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Avelumab in patients with previously treated metastatic Merkel cell carcinoma: long-term data and biomarker analyses from the single-arm phase 2 JAVELIN Merkel 200 trial.

D'Angelo SP, Bhatia S, Brohl AS, Hamid O, Mehnert JM, Terheyden P, Shih KC, Brownell I, Lebbé C, Lewis KD, Linette GP, Milella M, Georges S, Shah P, Ellers-Lenz B, Bajars M, Güzel G, Nghiem PT

J Immunother Cancer . 2020 May;8(1):e000674. doi: 10.1136/jitc-2020-000674.

PMID: 32414862

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Neoadjuvant Nivolumab for Patients With Resectable Merkel Cell Carcinoma in the CheckMate 358 Trial

Topalian SL, Bhatia S, Amin A, Kudchadkar RR, Sharfman WH, Lebbé C, Delord JP, Dunn LA, Shinohara MM, Kulikauskas R, Chung CH, Martens UM, Ferris RL, Stein JE, Engle EL, Devriese LA, Lao CD, Gu J, Li B, Chen T, Barrows A, Horvath A, Taube JM, Nghiem

J Clin Oncol. 2020 Apr 23:JCO2000201. doi: 10.1200/JCO.20.00201

PMID: 32324435

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High somatostatin receptor expression and efficacy of somatostatin analogues in patients with metastatic Merkel cell carcinoma

T Akaike, J Qazi, A Anderson, F S Behnia, M M Shinohara, G Akaike, D S Hippe, H Thomas, S R Takagishi, K Lachance, S Y Park, E S Tarabadkar, J G Iyer, A Blom, U Parvathaneni, H Vesselle, P Nghiem, S Bhatia

Br J Dermatol. 2020 Apr 22. doi: 10.1111/bjd.19150.

PMID: 32320473

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Polyomavirus‐driven Merkel cell carcinoma: Prospects for therapeutic vaccine development

Tabachnick‐Cherny S, Pulliam T, Church C, Koelle D, Nghiem P

Mol Carcinog. 2020 Mar 27. doi: 10.1002/mc.23190.

PMID: 32219902

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Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma

Shailender B, Longino NV, Miller NJ, Kulikauskas R, Iyer JG, Ibrani D, Blom A, Byrd DR, Parvathaneni U, Twitty CG, Campbell JS, Le MH, Gargosky S, Pierce RH, Heller R, Daud AI, and Nghiem P

Clin Cancer Res. 2020 Feb 1;26(3):598-607. doi: 10.1158/1078-0432.CCR-19-0972.

PMID: 31582519

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2019

Patterns of distant metastases in 215 Merkel cell carcinoma patients: Implications for prognosis and surveillance

Lewis CW, Qazi J, Hippe DS, Lachance K, Thomas H, Cook MM, Juhlin I, Singh N, Thuesmunn Z, Takagishi SR, McEvoy A, Doolittle-Amieva C, Bhatia S, Paulson KG, O'Malley RB, Wang CL, Nghiem P

Cancer Med. 2019 Dec 27. doi: 10.1002/cam4.2781.

PMID: 31883234

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Identification of Therapeutic Vulnerabilities in Small Cell Neuroendocrine Prostate Cancer

Corella AN, Cabiliza Ordonio MVA, Coleman I, Lucas JM, Kaipainen A, Nguyen HM, Sondheim D, Brown L, True LD, Lee JK, MacPherson D, Nghiem P, Gulati R, Morrissey C, Corey E, Nelson PS

Clin Cancer Res. 2019 Dec 5. pii: clincanres.0775.2019. doi: 10.1158/1078-0432.CCR-19-0775

PMID: 31806643

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Imaging of Merkel Cell Carcinoma: What Imaging Experts Should Know

Akaike G, Akaike T, Fadl SA, Lachance K, Nghiem P, Behnia F

Radiographics. 2019 Nov-Dec;39(7):2069-2084. doi: 10.1148/rg.2019190102.

PMID: 31697628

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Less Toxic, More Effective Treatment—A Win-Win for Patients With Merkel Cell Carcinoma

Nghiem P, Park SY

JAMA Dermatol. 2019 Sep 4. doi: 10.1001/jamadermatol.2019.2584.

PMID: 31483436

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Human CD4+ T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain

Longino NV, Yang J, Iyer JG, Ibrani D, Chow IT, Laing KJ, Campbell VL, Paulson KG, Kulikauskas RM, Church CD, James EA, Nghiem P, Kwok WW, Koelle DM

Cancer Immunol Res. 2019 Oct;7(10):1727-1739. doi: 10.1158/2326-6066.CIR-19-0103.

PMID: 31405946

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Treatment Patterns, Overall Survival, and Total Healthcare Costs of Advanced Merkel Cell Carcinoma in the USA

Steuten L, Garmo V, Phatak H, Sullivan SD, Nghiem P, Ramsey SD.

Appl Health Econ Health Policy. 2019 Jun 28. doi: 10.1007/s40258-019-00492-5. [Epub ahead of print]

PMID: 31250217

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One in a hundred million: Merkel cell carcinoma in pediatric and young adult patients is rare but more likely to present at advanced stages based on US registry data.

Paulson K, Nghiem P

J Am Acad Dermatol. 2019 Jun;80(6):1758-1760. doi: 10.1016/j.jaad.2018.08.021.

PMID: 30165170

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Travel burden associated with rare cancers: The example of Merkel cell carcinoma.

Jain R, Menzin J, Lachance K, McBee P, Phatak H, Nghiem PT.

Cancer Med. 2019 May;8(5):2580-2586. doi: 10.1002/cam4.2085. Epub 2019 Apr 5.

PMID: 30950224

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Durable Tumor Regression and Overall Survival in Patients With Advanced Merkel Cell Carcinoma Receiving Pembrolizumab as First-Line Therapy.

Nghiem P, Bhatia S, Lipson EJ, Sharfman WH, Kudchadkar RR, Brohl AS, Friedlander PA, Daud A, Kluger HM, Reddy SA, Boulmay BC, Riker AI, Burgess MA, Hanks BA, Olencki T, Margolin K, Lundgren LM, Soni A, Ramchurren N, Church C, Park SY, Shinohara MM, Salim B, Taube JM, Bird SR, Ibrahim N, Fling SP, Homet Moreno B, Sharon E, Cheever MA, Topalian SL.

J Clin Oncol. 2019 Mar 20;37(9):693-702. doi: 10.1200/JCO.18.01896. Epub 2019 Feb 6.

PMID: 30726175

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Early objective response to avelumab treatment is associated with improved overall survival in patients with metastatic Merkel cell carcinoma.

D'Angelo SP, Hunger M, Brohl AS, Nghiem P, Bhatia S, Hamid O, Mehnert JM, Terheyden P, Shih KC, Brownell I, Lebbé C, Lewis KD, Linette GP, Milella M, Schlichting M, Hennessy MH, Bharmal M.

Cancer Immunol Immunother. 2019 Apr;68(4):609-618. doi: 10.1007/s00262-018-02295-4. Epub 2019 Feb 5.

PMID: 30721341

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Tuberculosis following PD-1 blockade for cancer immunotherapy

Barber DL, Sakai S, Kudchadkar RR, Fling SP, Day TA, Vergara JA, Ashkin D, Cheng JH, Lundgren LM, Raabe VN, Kraft CS, Nieva JJ, Cheever MA, Nghiem PT, Sharon E

Sci Transl Med. 2019 Jan 16;11(475). pii: eaat2702. doi: 10.1126/scitranslmed.aat2702.

PMID: 30651320

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Differential Outcomes Among Immunosuppressed Patients With Merkel Cell Carcinoma: Impact of Immunosuppression Type on Cancer-specific and Overall Survival.

Cook M, Baker K, Redman M, Lachance K, Nguyen MH, Parvathaneni U, Bhatia S, Nghiem P, Tseng YD.

Am J Clin Oncol. 2019 Jan;42(1):82-88. doi: 10.1097/COC.0000000000000482.

PMID: 30211723

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2018

The biology and treatment of Merkel cell carcinoma: current understanding and research priorities.

Harms PW, Harms KL, Moore PS, DeCaprio JA, Nghiem P, Wong MKK, Brownell I

Nat Rev Clin Oncol. 2018 Dec;15(12):763-776. doi: 10.1038/s41571-018-0103-2.

PMID: 30287935

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Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy

Miller N, Church C, Fling S, Kulikauskas R, Ramchurren N, Shinohara M, Kluger H, Bhatia S, Lundgren L, Cheever M, Topalian S, Nghiem P

J Immunother Cancer. 2018 Nov 27;6(1):131. doi: 10.1186/s40425-018-0450-7.

PMID: 30482247

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T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide–MHC complexes

Bentzen A, Such L, Jensen K, Marquard A, Jessen L, Miller N, Church C, Lyngaa R, Koelle D, Becker J, Linnemann C, Schumacher T, Marcatili P, Nghiem P, Nielsen M, Hadrup S

Nat Biotechnol. 2018 Nov 19. doi: 10.1038/nbt.4303.

PMID: 30451992

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Multidimensional, quantitative assessment of PD-1/PD-L1 expression in patients with Merkel cell carcinoma and association with response to pembrolizumab.

Giraldo NA, Nguyen P, Engle EL, Kaunitz GJ, Cottrell TR, Berry S, Green B, Soni A, Cuda JD, Stein JE, Sunshine JC, Succaria F, Xu H, Ogurtsova A, Danilova L, Church CD, Miller NJ, Fling S, Lundgren L, Ramchurren N, Yearley JH, Lipson EJ, Cheever M, Anders RA, Nghiem PT, Topalian SL, Taube JM

J Immunother Cancer. 2018 Oct 1;6(1):99. doi: 10.1186/s40425-018-0404-0.

PMID: 30285852

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Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.

Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG.

Nat Commun. 2018 Sep 24;9(1):3868. doi: 10.1038/s41467-018-06300-3.

PMID: 30250229

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Intratumoral G100, a TLR4 agonist, induces anti-tumor immune responses and tumor regression in patients with Merkel cell carcinoma.

Bhatia S, Miller NJ, Lu H, Vandeven NV, Ibrani D, Shinohara M, Byrd D, Parvathaneni U, Kulikauskas RM, Ter Meulen J, Hsu FJ, Koelle DM, Nghiem P

Clin Cancer Res. 2018 Aug 9. pii: clincanres.0469.2018.

PMID: 30093453

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Targeting Merkel cell carcinoma by engineered T cells specific to T-antigens of Merkel cell polyomavirus.

Gavvovidis I, Leisegang M, Willimsky G, Miller NJ, Nghiem P, Blankenstein T.

Clin Cancer Res. 2018 Aug 1;24(15):3644-3655.

PMID: 29669806

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Circulating cell-free miR-375 as surrogate marker of tumor burden in Merkel cell carcinoma.

Kaiji Fan, Cathrin Ritter, Paul Nghiem, Astrid Blom, Monique E Verhaegen, Andrzej Dlugosz, Niels Odum, Anders Woetmann, Richard W. Tothill, Rodney J. Hicks, Michael Sand, David Schrama, Dirk Schadendorf, Selma Ugurel and Jurgen C Becker

Clin Cancer Res 2018

PMID: 30061360

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Merkel Cell Carcinoma, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.

Bichakjian CK, Olencki T, Aasi SZ, Alam M, Andersen JS, Blitzblau R, Bowen GM, Contreras CM, Daniels GA, Decker R, Farma JM, Fisher K, Gastman B, Ghosh K, Grekin RC, Grossman K, Ho AL, Lewis KD, Loss M, Lydiatt DD, Messina J, Nehal KS, Nghiem P, Puzanov I, Schmults CD, Shaha AR, Thomas V, Xu YG, Zic JA, Hoffmann KG, Engh AM.

J Natl Compr Canc Netw. 2018 Jun;16(6):742-774

PMID: 29891526

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Effect of Patient Immune Status on the Efficacy of Radiation Therapy and Recurrence-Free Survival Among 805 Patients With Merkel Cell Carcinoma.

Tseng YD, Nguyen MH, Baker K, Cook M, Redman M, Lachance K, Bhatia S, Liao JJ, Apisarnthanarax S, Nghiem PT, Parvathaneni U.

Int J Radiat Oncol Biol Phys. 2018 Oct 1;102(2):330-339. doi: 10.1016/j.ijrobp.2018.05.075. Epub 2018 Jun 5.

PMID: 30191867

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The association between geographic location and incidence of Merkel cell carcinoma in comparison to melanoma: An international assessment.

Stang A, Becker JC, Nghiem P, Ferlay J

Eur J Cancer. 2018 May;94:47-60

PMID: 29533867

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Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes.

Colunga A, Pulliam T, Nghiem P.

Clin Cancer Res. 2018 May 1;24(9):2035-2043.

PMID: 29217527

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Clinical Benefit from Tyrosine Kinase Inhibitors in Metastatic Merkel Cell Carcinoma: A Case Series of 5 Patients.

Tarabadkar ES, Thomas H, Blom A, Parvathaneni U, Olencki T, Nghiem P, Bhatia S.

Am J Case Rep 2018; 19:505-511

PMID: 29706615

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Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC.

Becker JC, Stang A, zur Hausen A, Fischer N, DeCaprio JA, Tothill RW, Lyngaa R, Hansen UK, Ritter C, Nghiem P, Bichakjian CK, Ugurel S, Schrama D.

Cancer Immunol Immunother. 2018 Mar;67(3):341-351.

PMID: 29188306

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Merkel cell carcinoma: Current US incidence and projected increases based on changing demographics.

Paulson KG, Park SY, Vandeven NA, Lachance K, Thomas H, Chapuis AG, Harms KL, Thompson JA, Bhatia S, Stang A, Nghiem P.

J Am Acad Dermatol. 2018 Mar;78(3):457-463.

PMID: 29102486

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Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival.

Vandeven N, Lewis CW, Makarov V, Riaz N, Paulson KG, Hippe D, Bestick A, Doumani R, Marx T, Takagishi S, Chan TA, Choi J, Nghiem P.

Clin Cancer Res. 2018 Feb 15;24(4):963-971.

PMID: 29246939

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Updated efficacy of avelumab in patients with previously treate metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trail.

Kaufman HL, Russell JS, Hamid O, Bhatia S, Terheyden P, D’Angelo SP, Shih KC, Lebbé C, Milella M, Brownell I, Lewis KD, Lorch JH, von Heydebreck A, Hennessy M, Nghiem P.

J Immunother Cancer. 2018 Jan 19;6(1):7.

PMID: 29347993

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2017

Merkel Cell Carcinoma

Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P

Nat Rev Dis Primers. 2017 Oct 26;3:17077.

PMID: 29072302

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CD200 Expression in Neuroendocrine Neoplasms.

Love JE, Thompson K, Kilgore MR, Westerhoff M, Murphy CE, Papanicolau-Sengos A, McCormick KA, Shankaran V, Vandeven N, Miller F, Blom A, Nghiem PT, Kussick SJ.

Am J Clin Pathol. 2017 Sep 1;148(3):236-242.

PMID: 28821198

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Immune evasion mechanisms and immune checkpoint inhibition in advanced merkel cell carcinoma.

Schadendorf D, Nghiem P, Bhatia S, Hauschild A, Saiag P, Mahnke L, Hariharan S, Kaufman HL.

Oncoimmunology. 2017 Aug 31;6(10):e1338237.

PMID: 29123950

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Systematic literature review of efficacy, safety and tolerability outcomes of chemotherapy regimens in patients with metastatic Merkel cell carcinoma.

Nghiem P, Kaufman HL, Bharmal M, Mahnke L, Phatak H, Becker JC.

Future Oncol. 2017 Jun;13(14):1263-1279.

PMID: 28350180

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Epigenetic priming restores the HLA class-I antigen processing machinery expression in Merkel cell carcinoma.

Ritter C, Fan K, Paschen A, Reker S, Ferrone S, Nghiem P, Ugurel S, Schrama D, Becker JC.

Sci Rep. 2017 May 23;7(1):2290.

PMID: 28536458

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Viral oncoprotein antibodies as a marker for recurrence of Merkel cell carcinoma: A prospective validation study.

Paulson KG, Lewis CW, Redman MW, Simonson WT, Lisberg A, Ritter D, Morishima C, Hutchinson K, Mudgistratova L, Blom A, Iyer J, Moshiri AS, Tarabadkar ES, Carter JJ, Bhatia S, Kawasumi M, Galloway DA, Wener MH, Nghiem P.

Cancer. 2017 Apr 15;123(8):1464-1474.

PMID: 27925665

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DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing.

Calses PC, Dhillon KK, Tucker N, Chi Y, Huang J, Kawasumi M, Nghiem P, Wang Y, Clurman BE, Jacquemont C, Gafken PR, Sugasawa K, Saijo M, Taniguchi T.

Cell Rep. 2017 Apr 4;19(1):162-174.

PMID: 28380355

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Polyomavirus-Negative Merkel Cell Carcinoma: A More Aggressive Subtype Based on Analysis of 282 Cases Using Multimodal Tumor Virus Detection.

Moshiri AS, Doumani R, Yelistratova L, Blom A, Lachance K, Shinohara MM, Delaney M, Chang O, McArdle S, Thomas H, Asgari MM, Huang ML, Schwartz SM, Nghiem P.

J Invest Dermatol. 2017 Apr;137(4):819-827.

PMID: 27815175

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Factors influencing radiation treatment recommendations in early-stage Merkel cell carcinoma: a survey of US-based radiation oncologists.

Tseng YD, Apisarnthanarax S, Liao JJ, Bhatia S, Nghiem PT, Parvathaneni U.

Expert Rev Anticancer Ther. 2017 Mar;17(3):281-287.

PMID: 28103445

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Tumor-Infiltrating Merkel Cell Polyomavirus-Specific T Cells Are Diverse and Associated with Improved Patient Survival.

Miller NJ, Church CD, Dong L, Crispin D, Fitzgibbon MP, Lachance K, Jing L, Shinohara M, Gavvovidis I, Willimsky G, McIntosh M, Blankenstein T, Koelle DM, Nghiem P.

Cancer Immunol Res. 2017 Feb;5(2):137-147.

PMID: 28093446

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2016

Postoperative radiation therapy is associated with a reduced risk of local recurrence among low risk Merkel cell carcinomas of the head and neck.

Takagishi SR, Marx TE, Lewis C, Tarabadker ES, Juhlin ID, Blom A, Iyer JG, Liao JJ, Tseng YD, Fu T, Nghiem P, Parvathaneni U.

Adv Radiat Oncol. 2016 Oct 20;1(4):244-251.

PMID: 28740894

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Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial.

Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P.

Lancet Oncol. 2016 Oct;17(10):1374-1385.

PMID: 27592805

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Analysis of Prognostic Factors from 9387 Merkel Cell Carcinoma Cases Forms the Basis for the New 8th Edition AJCC Staging System.

Harms KL, Healy MA, Nghiem P, Sober AJ, Johnson TM, Bichakjian CK, Wong SL.

Ann Surg Oncol. 2016 Oct;23(11):3564-3571.

PMID: 27198511

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Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations.

Iyer JG, Parvathaneni K, Bhatia S, Tarabadkar ES, Blom A, Doumani R, McKenzie J, Asgari MM, Nghiem P.

J Am Acad Dermatol. 2016 Sep;75(3):541-547.

PMID: 27177440

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Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma.

Iyer JG, Blom A, Doumani R, Lewis C, Tarabadkar ES, Anderson A, Ma C, Bestick A, Parvathaneni U, Bhatia S, Nghiem P.

Cancer Med. 2016 Sep;5(9):2294-301.

PMID: 27431483

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Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas.

Vandeven N, Nghiem P.

Immunotherapy. 2016 Jul;8(8):907-21.

PMID: 27381685

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PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma.

Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP, Friedlander PA, Kluger HM, Kohrt HE, Lundgren L, Margolin K, Mitchell A, Olencki T, Pardoll DM, Reddy SA, Shantha EM, Sharfman WH, Sharon E, Shemanski LR, Shinohara MM, Sunshine JC, Taube JM, Thompson JA, Townson SM, Yearley JH, Topalian SL, Cheever MA.

N Engl J Med. 2016 Jun 30;374(26):2542-52.

PMID: 27093365

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Adjuvant Radiation Therapy and Chemotherapy in Merkel Cell Carcinoma: Survival Analyses of 6908 Cases From the National Cancer Data Base.

Bhatia S, Storer BE, Iyer JG, Moshiri A, Parvathaneni U, Byrd D, Sober AJ, Sondak VK, Gershenwald JE, Nghiem P.

J Natl Cancer Inst. 2016 May 31;108(9).

PMID: 27245173

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Basal Cell Skin Cancer, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology.

Bichakjian CK, Olencki T, Aasi SZ, Alam M, Andersen JS, Berg D, Bowen GM, Cheney RT, Daniels GA, Glass LF, Grekin RC, Grossman K, Higgins SA, Ho AL, Lewis KD, Lydiatt DD, Nehal KS, Nghiem P, Olsen EA, Schmults CD, Sekulic A, Shaha AR, Thorstad WL, Tuli M, Urist MM, Wang TS, Wong SL, Zic JA, Hoffmann KG, Engh A.

J Natl Compr Canc Netw. 2016 May;14(5):574-97.

PMID: 27160235

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Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.

Ritter C, Fan K, Paulson KG, Nghiem P, Schrama D, Becker JC.

Sci Rep. 2016 Feb 23;6:21678.

PMID: 26902929

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Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.

Ritter C, Fan K, Paulson KG, Nghiem P, Schrama D, Becker JC.

Sci Rep. 2016 Feb 23;6:21678.

PMID: 26902929

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Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy.

Goh G, Walradt T, Markarov V, Blom A, Riaz N, Doumani R, Stafstrom K, Moshiri A, Yelistratova L, Levinsohn J, Chan TA, Nghiem P, Lifton RP, Choi J.

Oncotarget. 2016 Jan 19;7(3):3403-15.

PMID: 26655088

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2015

Single fraction radiation therapy in patients with metastatic Merkel cell carcinoma.

Iyer JG, Parvathaneni U, Gooley T, Miller NJ, Markowitz E, Blom A, Lewis CW, Doumani RF, Parvathaneni K, Anderson A, Bestick A, Liao J, Kane G, Bhaftia S, Paulson K, Nghiem P.

Cancer Med. 2015 Aug;4(8):1161-70.

PMID: 25908228

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How does the Merkel polyomavirus transform cells? Many answers, many questions, and a new mouse model.

Church C., Nghiem P.

J Invest Dermatol. 2015 May;135(5):1221-1224.

PMID: 25882464

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2014

Identification of ATR-Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity.

Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P.

Cancer Res. 2014 Dec 15;74(24):7534-45.

PMID: 25336189

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Downregulation of MHC-1 expression is prevalent but reversible in Merkel cell carcinoma.

Paulson KG, Tegeder A, Willmes C, Iyer JG, Afanasiev OK, Schrama D, Koba S, Thibodeau R, Nagase K, Simonson WT, Seo A, Koelle DM, Madeleine M, Bhatia S, Nakajima H, Sano S, Hardwick JS, Disis ML, Cleary MA, Becker JC, Nghiem P.

Cancer Immunol Res. 2014 Nov;2(11):1071-9.

PMID: 25116754

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CD8+ lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival: a population-based study.

Paulson KG, Iyer JG, Simonson WT, Blom A, Thibodeau RM, Schmidt M, Pietromonaco S, Sokil M, Warton EM, Asgari MM, Nghiem P.

Am J Clin Pathol. 2014 Oct;142(4):452-8.

PMID: 25239411

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Milestones in the staging, classification, and biology of Merkel cell carcinoma.

Moshiri AS, Nghiem P.

J Natl Compr Canc Netw. 2014 Sep;12(9):1255-62.

PMID: 25190694

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Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma.

Asgari MM, Sokil MM, Warton EM, Iyer J, Paulson KG, Nghiem P.

JAMA Dermatol. 2014 Jul;150(7):716-23.

PMID: 24807619

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Inhibition of UVB-induced nonmelanoma skin cancer: a path from tea to caffeine to exercise to decreased tissue fat.

Conney AH, Lou YR, Nghiem P, Bernard JJ, Wagner GC, Ju YP.

Top Curr Chem. 2013;329:61-72.

PMID: 22752580

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T-cell Responses to Oncogenic Merkel Cell Polyomavirus Proteins Distinguish Patients with Merkel Cell Carcinoma from Healthy Donors.

Lyngaa R, Pedersen NW, Schrama D, Thrue CA, Ibrani D, Met Ö, Thor Straten P, Nghiem P, Becker JC, Hadrup SR.

Clin Cancer Res. 2014 Apr 1;20(7):1768-78.

PMID: 24526738

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Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma.

Iyer, JG, Storer, BE, Paulson, KG, Lemos, B, Phillips, JL, Bichakjian C, Zeitouni N, Gershenwald JE, Sondak V, Otley CC, Yu SS, Johnson TM, Liegeois NJ, Byrd D, Sober A, Nghiem P

J Am Acad Dermatol. 2014 Apr;70(4):637-643.

PMID: 24521828

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Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma.

Blom A, Bhatia S, Pietromonaco S, Koehler K, Iyer JG, Nagase K, Paulson K, Sabath DE, Nghiem P.

J Am Acad Dermatol. 2014 Mar;70(3):449-55.

PMID: 24388423

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Merkel cell carcinoma, version 1.2014.

Bichakjian CK, Olencki T, Alam M, Andersen JS, Berg D, Bowen GM, Cheney RT, Daniels GA, Glass LF, Grekin RC, Grossman K, Ho AL, Lewis KD, Lydiatt DD, Morrison WH, Nehal KS, Nelson KC, Nghiem P, Perlis CS, Shaha AR, Thorstad WL, Tuli M, Urist MM, Wang TS, Werchniak AE, Wong SL, Zic JA, Hoffmann KG, McMillian NR, Ho M.

J Natl Compr Canc Netw. 2014 Mar 1;12(3):410-24.

PMID: 24616545

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Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of reinducing HLA class-I.

Chapuis AG, Afanasiev OK, Iyer JG, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya KC, Gooley T, Desmarais C, Koelle DM, Yee C, Nghiem P.

Cancer Immunol Res. 2014 Jan;2(1):27-36.

PMID: 24432305

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Pathogen-driven cancers and emerging immune therapeutic strategies.

Vandeven N, Nghiem P.

Cancer Immunol Res. 2014 Jan;2(1):9-14.

PMID: 24778160

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2013

Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.

Bhatia S, Afanasiev O, Nghiem P.

Curr Oncol Rep. 2011 Dec;13(6):488-97.

PMID: 21953511

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Mechanisms of caffeine-induced inhibition of UVB carcinogenesis.

Conney AH, Lu Y-P, Lou Y-R, Kawasumi M, Nghiem P.

Front Oncol. 2013 Jun 17;3:144.

PMID: 23785666

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Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinoma.

Miller NJ, Bhatia S, Parvathaneni U, Iyer JG, Nghiem P.

Curr Treat Options Oncol. 2013 Jun;14(2):249-63.

PMID: 23436166

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Merkel cell polyomavirus large T antigen has growth promoting and inhibitory activities.

Cheng J, Rozenblatt-Rosen O, Paulson KG, Nghiem P, DeCaprio JA.

J Virol. 2013 Jun;87(11):6118-26.

PMID: 23514892

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p63 expression in Merkel cell carcinoma predicts poorer survival yet may have limited clinical utility.

Stetsenko Gy, Malekirad J, Paulson KG, Iyer JG, Thibodeau Rm, Nagase K, Schmidt M, Storer BE, Argenyi ZB, Nghiem P.

Am J Clin Pathol. 2013 Dec;140(6):838-44.

PMID: 24225752

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Merkel cell polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.

Afanasiev OK, Yelistratova L, Miller N, Nagase K, Paulson KG, Iyer JG, Ibrani D, Koelle DM, Nghiem P.

Clin Cancer Res. 2013 Oct 1;19(19):5351-60.

PMID: 23922299

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Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma.

Afanasiev OK, Nagase K, Simonson W, Vandeven N, Blom A, Koelle DM, Clark R, Nghiem P.

J Invest Dermatol. 2013 Aug;133(8):2065-73.

PMID: 23353989

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Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses.

Dowlatshahi M, Huang V, Gehad A, Jiang Y, Calarese A, Teague JE, Dorosario A, Cheng J, Nghiem P, Schanbacher C, Thakuria M, Schmults C, Wang LC, Clark RA.

J Invest Dermatol. 2013 Jul;133(7):1879-89.

PMID: 23419694

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Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage.

Paulson KG, Iyer JG, Blom A, Warton EM, Sokil M, Yelistratova L, Schuman L Nagase K, Bhatia S, Asgari MM, Nghiem P.

J Invest Dermatol. 2013 Mar;133(3):642-646.

PMID: 23190897

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2012

Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma.

Koba S, Paulson KG, Nagase K, Tegeder A, Thibodeau R, Iyer JG, Narisawa Y, Nghiem P.

PLoS One. 2012;7(7):e41465.

PMID: 22859987

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Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet.

Lu YP, Lou YR, Bernard JJ, Peng QY, Li T, Lin Y, Shih WJ, Nghiem P, Shapses S, Wagner GC, Conney AH.

Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9065-70.

PMID: 22615388

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2011

A new American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma: Creation and rationale for inclusion of tumor (T) characteristics.

Farasat S, Yu SS, Neel VA, Nehal KS, Lardaro T, Mihm MC, Byrd DR, Balch CM, Califano JA, Chuang AY, Sharfman WH, Shah JP, Nghiem P, Otley CC, Tufaro AP, Johnson TM, Sober AJ, Liégeois NJ.

J Am Acad Dermatol. 2011 Jun;64(6):1051-9.

PMID: 21255868

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Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas.

Lee S, Paulson KG, Murchison EP, Afanasiev OK, Alkan C, Leonard JH, Byrd DR, Hannon GJ, Nghiem PT.

J Clin Virol. 2011 Nov;52(3):272-5.

PMID: 21907614

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Merkel cell polyomavirus-specific CD8+ and CD4+ T-cell responses identified in Merkel cell carcinomas and blood.

Iyer JG, Afanasiev OK, McClurkan C, Paulson KG, Nagase K, Jing L, Marshak J, Dong L, Carter JJ, Lai I, Farrar E, Byrd D, Galloway D, Yee C, Koelle DM, Nghiem P.

Clin Cancer Res. 2011 Nov 1;17(21):6671-80.

PMID: 21908576

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Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase.

Kawasumi M, Lemos B, Bradner JE, Thibodeau R, Kim YS, Schmidt M, Higgins E, Koo SW, Angle-Zahn A, Chen A, Levine D, Nguyen L, Heffernan TP, Longo I, Mandinova A, Lu YP, Conney AH, Nghiem P.

Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13716-21.

PMID: 21844338

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Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States.

Paulson KG, Iyer JG, Nghiem P.

J Am Acad Dermatol. 2011 Jul;65(1):35-9.

PMID: 21514002

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Caffeine decreases phospho-Chk1 (Ser317) and increases mitotic cells with cyclin B1 and caspase 3 in tumors from UVB-treated mice.

Lu Y-P, Lou Y-R, Peng Q-Y, Nghiem P, Conney A H.

Cancer Prev Res (Phila). 2011 Jul;4(7):1118-25.

PMID: 21505179

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Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.

Huryn D, Brodsky J, Brummond K, Chambers P, Eyre B, Ireland A, Kawasumi M, LaPorte M, Lloyd K, Manteau B, Nghiem P, Quade B, Wipf P.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62.

PMID: 21502524

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Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival.

Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR, Koelle DM, Galloway DA, Leonard JH, Madeleine MM, Argenyi AB, Disis ML, Becker JC, Cleary MA, Nghiem P.

J Clin Oncol. 2011 Apr 20;29(12):1539-46.

PMID: 21422430

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2010

Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5,823 cases as the basis of the first consensus staging system for this cancer.

Lemos B, Storer B, Iyer J, Phillips JL, Bichakjian CK, Fang LC, Johnson TM, Liegeois-Kwon NJ, Otley CC, Paulson KG, Ross MI, Yu SS, Zeitouni NC, Byrd DR, Sondak VK, Gershenwald JE, Sober AJ, Nghiem P.

J Am Acad Dermatol. 2010 Nov;63(5):751-61.

PMID: 20646783

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Antibodies to Merkel cell polyomavirus T-antigen oncoproteins reflect Merkel cell carcinoma tumor burden.

Paulson KG, Carter JJ, Johnson LG, Cahill KW, Iyer JG, Schrama D, Becker JC, Madeleine MM, Nghiem P, Galloway DA.

Cancer Res. 2010 Nov 1;70(21):8388-97.

PMID: 20959478

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Basal cell and squamous cell skin cancers.

Miller SJ, Alam M, Andersen J, Berg D, Bichakjian CK, Bowen G, Cheney RT, Glass LF, Grekin RC, Kessinger A, Lee NY, Liegeois N, Lydiatt DD, Michalski J, Morrison WH, Nehal KS, Nelson KC, Nghiem P, Olencki T, Perlis CS, Rosenberg EW, Shaha AR, Urist MM, Wang LC, Zic JA.

J Natl Compr Canc Netw. 2010 Aug;8(8):836-64.

PMID: 20870631

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Radiation monotherapy as regional treatment for node-positive Merkel cell carcinoma.

Fang LC, Lemos B, Douglas J, Iyer J, Nghiem P.

Cancer. 2010 Apr 1;116(7):1783-90. doi: 10.1002/cncr.24919.

PMID: 20162707

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2009

Toward better management of Merkel cell carcinoma using a consensus staging system, new diagnostic codes and a recently discovered virus.

Iyer JG, Koba S, Nghiem P.

Actas Dermosifiliogr. 2009 Dec;100 Suppl 2:49-54.

PMID: 20096162

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Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma

Carter JJ, Paulson KG, Wipf GC, Miranda D, Madeleine MM, Johnson LG, Lemos BD, Lee S, Warcola AH, Iyer JG, Nghiem P, Galloway D.

J Natl Cancer Inst. 2009 Nov 4;101(21):1510-22.

PMID: 19776382

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ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.

Heffernan TP, Kawasumi M, Blasina A, Anderes K, Conney AH, Nghiem P.

J Invest Dermatol. 2009 Jul;129(7):1805-15.

PMID: 19242509

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Array-CGH Reveals Recurrent Genomic Changes in Merkel Cell Carcinoma Including Amplification of L-Myc.

Paulson KG, Lemos BD, Feng B, Jaimes N, Peñas PF, Bi X, Maher E, Cohen L, Leonard JH, Granter SR, Chin L, Nghiem P.

J Invest Dermatol. 2009 Jun;129(6):1547-55.

PMID: 19020549

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Merkel Cell Carcinoma

Miller SJ, Alam M, Andersen J, Berg D, Bichakjian CK, Bowen G, Cheney RT, Glass LF, Grekin RC, Hallahan DE, Kessinger A, Lee NY, Liegeois N, Lydiatt DD, Michalski J, Morrison WH, Nehal KS, Nelson KC, Nghiem P, Olencki T, Oseroff AR, Perlis CS, Rosenberg EW, Shaha AR, Urist MM, Wang LC.

J Natl Compr Canc Netw. 2009 Mar;7(3):322-32.

PMID: 19401064

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Merkel cell polyomavirus is not detected in prostate cancers, surrounding stroma, or benign prostate controls.

Bluemn EG, Paulson KG, Higgins EE, Sun Y, Nghiem P, Nelson PS.

J Clin Virol. 2009 Feb;44(2):164-6.

PMID: 19129009

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2008

Case 19-2008: Merkel-cell carcinoma.

Lemos BD, Yu SS, Nghiem P.

N Engl J Med. 2008 Oct 9;359(15):1629-30; author reply 1630-1.

PMID: 18843131

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Does a new polyomavirus contribute to Merkel cell carcinoma?

Garneski KM1, DeCaprio JA, Nghiem P.

Genome Biol. 2008;9(6):228.

PMID: 18598371

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Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice.

Lu YP, Lou YR, Pen QY, Xie JG, Nghiem P, Conney AH.

Cancer Res. 2008 Apr 1;68(7):2523-9.

PMID: 18381462

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2007

Merkel cell carcinoma: more deaths but still no pathway to blame.

Lemos B, Nghiem P.

J Invest Dermatol. 2007 Sep;127(9):2100-3.

PMID: 17700621

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Merkel cell carcinoma adjuvant therapy: current data support radiation but not chemotherapy.

Garneski KM, Nghiem P.

J Am Acad Dermatol. 2007 Jul;57(1):166-9. Epub 2007 May 7.

PMID: 17482714

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Chemical genetics: elucidating biological systems with small-molecule compounds.

Kawasumi M, Nghiem P.

J Invest Dermatol. 2007 Jul;127(7):1577-84.

PMID: 17568801

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Protection from photodamage by topical application of caffeine after ultraviolet irradiation.

Koo SW, Hirakawa S, Fujii S, Kawasumi M, Nghiem P.

Br J Dermatol. 2007 May;156(5):957-64. Epub 2007 Mar 28.

PMID: 17388926

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Dermatofibrosarcoma Protuberans Guidelines

Miller SJ, Alam M, Andersen J, Berg D, Bichakjian CK, Bowen G, Cheney RT, Glass F, Grekin RC, Grichnik JM, Kessinger A, Lee NY, Lessin S, Lydiatt DD, Margolis LW, Michalski J, Nehal KS, Nghiem P, Oseroff AR, Rosenberg EW, Shaha AR, Siegle RJ, Urist MM

J Natl Compr Canc Netw. 2007 May;5(5):550-5.

PMID: 17509257

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The Protective Role of a Small GTPase RhoE against UVB-induced DNA Damage in Keratinocytes.

Boswell SA, Ongusaha PP, Nghiem P, Lee SW.

J Biol Chem. 2007 Feb 16;282(7):4850-8. Epub 2006 Dec 14.

PMID: 17170105

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2006

Sentinel lymph node biopsy for evaluation and treatment of patients with Merkel Cell Carcinoma.

Gupta SG, Wang LC, Penas PF, Gellenthin M, Lee SJ, Nghiem P.

Arch Dermatol. 2006 Jun;142(6):685-90.

PMID: 16785370

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A robust small-molecule microarray platform for screening cell lysates.

Bradner JE, McPherson OM, Mazitschek R, Barnes-Seeman D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN.

Chem Biol. 2006 May;13(5):493-504.

PMID: 16720270

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Role of skin biopsy to confirm suspected acute graft vs. host disease: results of decision analysis.

Firoz B, Lee S, Nghiem, P, Qureshi A.

Arch Dermatol. 2006 Feb;142(2):175-82.

PMID: 16490845

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2004

HIV-1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX foci formation.

Zimmerman E, Chen J, Blackett J, DeHart J, Murala S, Andersen J, Ardon O, Nghiem P, Planelles V.

Mol Cell Biol. 2004 Nov;24(21):9286-94.

PMID: 15485898

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Tissue eosinophils and the perils of using skin biopsy specimens to distinguish between drug hypersensitivity and cutaneous graft-vs.-host disease.

Marra D, McKee P, Nghiem P.

J Am Acad Dermatol. 2004 Oct;51(4):543-6.

PMID: 15389188

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2003

Integration of growth factor and nutrient signaling: Implications for cancer biology.

Shamji S, Nghiem P, Schreiber S.

Mol Cell. 2003 Aug;12(2):271-80.

PMID: 14536067

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Activation of the ATR-mediated DNA Damage Response by the HIV-1 Viral Protein R.

Roshal M, Kim B, Zhu Y, Nghiem P, Planelles V.

J Biol Chem. 2003 Jul 11;278(28):25879-86. Epub 2003 May 8

PMID: 12738771

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2002

ATR Regulates Fragile Site Stability.

Casper A, Nghiem P, Arlt M, Glover T.

Cell. 2002 Dec 13;111(6):779-89.

PMID: 12526805

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ATR Regulates Fragile Site Stability.

Casper A, Nghiem P, Arlt M, Glover T.

Cell. 2002 Dec 13;111(6):779-89.

PMID: 12526805

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2001

Tacrolimus Ointment in the Treatment of Chronic Cutaneous Graft-vs.-Host Disease: A Case Series of 18 Patients.

Choi C, Nghiem P.

Arch Dermatol. 2001 Sep;137(9):1202-6.

PMID: 11559218

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ATR Inhibition Selectively Sensitizes G1 Checkpoint-Deficient Cells To Lethal Premature Chromatin Condensation.

Nghiem P, Park P, Kim Y, Vaziri C, Schreiber S.

Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9092-7.

PMID: 11481475

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2000

Identifying the Missing Link Between UV and p53: The Role of Phosphatidyl Inositol Kinase-Related Kinases.

Nghiem P.

J Am Acad Dermatol. 2000 Oct;43(4):706-7

PMID: 11004635

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1994

“Topical immunomodulators?”: introducing old friends and a new ally, tacrolimus.

Nghiem P, Ollick T, Gardner P, Schulman H.

Nature. 1994 Sep 22;371(6495):347-50.

PMID: 8090206

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Limiting Dilution Analysis of Ontogeny of Self- and Allo-Reactive Thymocytes of C57BL/6J Mouse.

Itoh T, Rao A, O'Brien D, Nghiem P, Cantor H.

Cytogenet Cell Genet. 1994;66(2):113-6.

PMID: 2256126

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Localization of the CAMKG Gene Encoding Gamma Isoforms of Multifunctional Calcium/calmodulin-dependent Protein Kinase (CaM Kinase) to Human Chromosome 10 Band q22 and Mouse Chromosome 14.

Li X, Nghiem P, Schulman H, Francke U.

Cytogenet Cell Genet. 1994;66(2):113-6.

PMID: 8287681

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1993

Cloning and Analysis of Two New Isoforms of Multifunctional Calcium/Calmodulin-dependent Protein Kinase Expressed in Multiple Human Tissues.

Nghiem P, Saati S, Martens C, Gardner P, Schulman H.

J Biol Chem. 1993 Mar 15;268(8):5471-9.

PMID: 8449910

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1992

Antisense Oligodeoxynucleotides to the Cystic Fibrosis Transmembrane Conductance Regulator Inhibit cAMP-activated but not Calcium-activated Chloride Currents.

Wagner JA, McDonald TV, Nghiem P, Lowe AW, Schulman H

Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6785-9.

PMID: 1379720

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Human Lymphocytes Transcribe the Cystic Fibrosis Transmembrane Conductance Regulator Gene and Exhibit CF-defective cAMP-regulated Chloride Current.

McDonald TV, Nghiem P, Gardner P, Martens CL.

Send to J Biol Chem. 1992 Feb 15;267(5):3242-8.

PMID: 1371114

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1991

Prostaglandin E1 Activates a Chloride Current in Jurkat T Lymphocytes via cAMP-Dependent Protein Kinase.

Maldonado D, Schumann M, Nghiem P, Dong Y, Gardner P.

FASEB J. 1991 Nov;5(14):2965-70.

PMID: 1721593

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