Localization of the CAMKG Gene Encoding Gamma Isoforms of Multifunctional Calcium/calmodulin-dependent Protein Kinase (CaM Kinase) to Human Chromosome 10 Band q22 and Mouse Chromosome 14.

Li X, Nghiem P, Schulman H, Francke U.

Cytogenet Cell Genet. 1994;66(2):113-6.

PMID: 8287681

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Multifunctional calcium/calmodulin-dependent protein kinase (CaM kinase) is an enzyme mediating calcium-dependent signal transduction pathways. CaM kinase exists in a variety of isoforms, each with a distinct tissue-specific expression pattern, that enables the kinase to regulate multiple functions in mammalian systems. Here we report the chromosomal localization of the previously cloned human gamma-CaM kinase gene (CAMKG). By using a mapping panel of human x Chinese hamster somatic cell hybrid lines and fluorescence in situ hybridization, we have assigned human CAMKG to chromosome 10q22. We have partially cloned the murine gamma-CaM kinase gene and mapped it Camkg to mouse chromosome 14 by analyzing a panel of mouse x rodent somatic cell hybrid lines. A recessive gene, asa, implicated in the control of autoimmune response, is located within the predicted region for Camkg.

Cytogenet Cell Genet. 1994;66(2):113-6.