Basic Research Publications

(Clinical & Merkel cell carcinoma publications listed separately)

 

  1. Itoh T, Rao A, O'Brien D, Nghiem P, Cantor H. Limiting Dilution Analysis of Ontogeny of Self- and Allo-Reactive Thymocytes of C57BL/6J Mouse. Thymus. 16:89-98, 1990.
  2. Nghiem P. Use of Highly Degenerate Primers to Amplify and Sequence Novel Target cDNA's. U. S. Biochemical Comments. 17(2):22-23, 1990.
  3. Maldonado D, Schumann M, Nghiem P, Dong Y, Gardner P. Prostaglandin E1 Activates a Chloride Current in Jurkat T Lymphocytes via cAMP-Dependent Protein Kinase. FASEB J. 5:2965-2970, 1991.
  4. Wagner JA, McDonald TV, Nghiem P, Lowe AW, Schulman H, Gruenert DC, Stryer L, Gardner P. Antisense Oligodeoxynucleotides to the Cystic Fibrosis Transmembrane Conductance Regulator Inhibit cAMP-activated but not Calcium-activated Chloride Currents. Proc. Natl. Acad. Sci. USA. 89: 6785-6789, 1992. [pdf]
  5. McDonald TV, Nghiem P, Gardner P, Martens CL. Human Lymphocytes Transcribe the Cystic Fibrosis Transmembrane Conductance Regulator Gene and Exhibit CF-defective cAMP-regulated Chloride Current. J. Biol. Chem. 267:3242-3248, 1992. [pdf]
  6. Paul Nghiem, Shahin Saati, Chris Martens, Phyllis Gardner, Howard Schulman. Cloning and Analysis of Two New Isoforms of Multifunctional Calcium/Calmodulin-dependent Protein Kinase Expressed in Multiple Human Tissues. J. Biol. Chem. 268: 5471-5479, 1993. [pdf]
  7. Li X, Nghiem P, Schulman H, Francke U. Localization of the CAMKG Gene Encoding Gamma Isoforms of Multifunctional Calcium/calmodulin-dependent Protein Kinase (CaM Kinase) to Human Chromosome 10 Band q22 and Mouse Chromosome 14. Cytogenet. Cell Genet. 66:113-116, 1994.
  8. Nghiem P, Ollick TN, Gardner PI, Schulman H. Interleukin-2 Transcriptional Block by Multifunctional CaM Kinase. Nature. 371:347-350, 1994.
  9. Nghiem P. Identifying the Missing Link Between UV and p53: The Role of Phosphatidyl Inositol Kinase-Related Kinases. J. Am. Acad. Dermatol. 43(4):706-707, 2000. [pdf]
  10. Choi C, Nghiem P. Tacrolimus Ointment in the Treatment of Chronic Cutaneous Graft-vs-Host Disease: A Case Series of 18 Patients. Arch. Dermatol. 137:75-76 , 2001. [pdf]
  11. * Nghiem P, Park P, Kim Y, Vaziri C, Schreiber S. ATR Inhibition Selectively Sensitizes G1 Checkpoint-Deficient Cells to Lethal Premature Chromatin Condensation. Proc. Natl. Acad. Sci. USA. 98:9092-9098, 2001. [pdf]
  12. * Nghiem P, Park P, Kim Y, Desai B, Taya Y, Schreiber S. ATR is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint. J. Biol. Chem. 277:4428-4434, 2002. [pdf]
  13. * Casper A, Nghiem P, Arlt M, Glover T. ATR Regulates Fragile Site Stability. Cell 111:779-789, 2002. [pdf]
  14. * Roshal M, Kim B, Zhu Y, Nghiem P, Planelles V. Activation of the ATR-mediated DNA damage response by the HIV-1 Viral protein R. J Biol Chem. 278:25879-25886, 2003. [pdf]
  15. Shamji, A, Nghiem, P, Schreiber, S. Integration of Growth Factor and Nutrient Signaling: Implications for Cancer Biology. Molecular Cell, 12:271-280, 2003. [pdf]
  16. Nghiem, P, Kim, Y., Schreiber, S. Protein Kinases as Targets in Cancer Therapy: Validated and Emerging Approaches. Chapter 13, pages 293-315: Oncogenomics: Molecular Approaches to Cancer. Eds: Brenner, C & Duggan, D. John Wiley and Sons Publisher, 2004. [pdf]
  17. Zimmerman ES, Chen J, Andersen JL, Ardon O, DeHart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V. Human Immunodeficiency Virus Type I Vpr-mediated G2 Arrest Requires Rad 17 and Hus1 and Induces Nuclear BRCA1 and Gamma-H2AX focus foration. Mol Cell Biol. 24(21):9286-94, 2004. [pdf]
  18. Bradner JE, McPherson OM, Mazitschek R, Barnes-Seean D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. A Robust Small-molecule Microarray Platform for Screening Cell Lysates. Chem Biol. 13(5):493-504, 2006. [pdf]
  19. Boswell SA, Ongusaha PP, Nghiem P, Lee SW. The Protective Role of a Small GTPase RhoE Against UVB-induced DNA Damage in Keratinocytes. J Biol Chem. 282(7):4850-4858, 2007. [pdf]
  20. *Kawasumi M, Nghiem P.  Chemical genetics: Elucidating biological systems with small molecules.  J Invest Dermatol. 127(7):1577-84, 2007. [pdf]
  21. *Koo S-W, Hirakawa S, Fujii S, Kawasumi M, Nghiem P.  Protection from photodamage by topical application of caffeine after UV. Br J Dermatol. 156:957, 2007. [pdf]

  22. *Lu YP, Lou YR, Peng QY, Xie JG, Nghiem P, Conney AH. Effect of Caffeine on the ATR/Chk1 Pathway in the Epidermis of UVB-Irradiated Mice. Can Res. 68(7):2523-2529, 2008. [pdf]
  23. *Heffernan T, Kawasumi M, Blasina A, Anderes K, Conney A, Nghiem P.  ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine.  J Invest Dermatol. 2009 [pdf]
  24. * Lemos B, Storer B, Iyer J, Phillips JL, Bichakjian CK, Fang LC, Johnson TM, Liegeois-Kwon NJ, Otley CC, Paulson KG, Ross MI, Yu SS, Zeitouni NC, Byrd DR, Sondak VK, Gershenwald JE, Sober AJ, Nghiem P. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5,823 cases as the basis of the first consensus staging system for this cancer. J Am Acad Dermatol. 2010. [pdf]
  25. Kelly G. Paulson*, Joseph J. Carter*, Lisa G. Johnson, Kevin W. Cahill, Jayasri G. Iyer, David Schrama, Juergen C. Becker, Margaret M. Madeleine, Paul Nghiem**, Denise A.Galloway**. Antibodies to Merkel cell polyomavirus T-antigen oncoproteins reflect Merkel cell carcinoma tumor burden. Can Res. 2010. [pdf]
  26. Kelly G. Paulson, Jayasri G. Iyer, Paul Nghiem. Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States. J Am Acad Dermatol. 2011 [pdf]
  27. Bhatia S, Afanasiev O, Nghiem P. Immunobiology of Merkel Cell Carcinoma: Implications for Immunotherapy of a Polyomavirus-Associated Cancer. Current Oncol Rep. 2011 [pdf]
  28. Kawasumi M, Lemos B, Bradner JE, Thibodeau R, Kim YS, Schmidt M, Higgins E, Koo SW, Angle-Zahn A, Chen A, Levine D, Nguyen L, Heffernan TP, Longo I, Mandinova A, Lu YP, Conney AH, Nghiem P. Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase. Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13716-21. doi: 10.1073/pnas.1111378108. Epub 2011 Aug 15. PMID: 21844338 [pdf]
  29. Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P. Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6757-62. doi: 10.1073/pnas.1015251108. Epub 2011 Apr 18. PMID: 21502524 [pdf]
  30. Conney AH, Lu Y-P, Lou Y-R, Kawasumi M, Nghiem P. Mechanisms of caffiene-induced inhibition of UBV carcinogenesis. Frontiers in Oncology, June 17, 2013, doi: 10.3389/fonc.2013.00144 [pdf]
  31. Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P. Identification of ATR-Chk1 pathway inhibitors that selectively target p53-deficient cells without directly suppressing ATR catalytic activity. Cancer Res. 2014 Dec 15;74(24):7534-45. doi: 10.1158/0008-5472.CAN-14-2650. Epub 2014 Oct 21. PMID: 25336189

 


High (*) and Highest (**) relevance to on-going work in the laboratory